Lung Cancer caused by over smoking Cigarette
A new study has revealed that smoking even just 15 cigarettes a day can cause a new mutation to appear in a smoker’s DNA each day. The scientists created a genetic map of the lung tumor of a 55-year-old man, which discovered 22,910 different mutations, most caused by carcinogenic agents found in cigarette smoke.
Lung cancer generally develops amongst those who have smoked an average of 365,000 cigarettes or the equivalent of a pack a day over 50 years. The scientists say that this average means that the patient probably developed a new mutation for every 15 cigarettes he smoked.
The scientist who leads the research, Peter Campbell of the Wellcome Tryst Sanger Institute, described the findings as ‘a little like Russian roulette.’ He said, “Every time you smoke a cigarette you are firing mutagens into the lung. Most do nothing but every so often they cause a mutation that can contribute to cancer. @”
The findings will go a long way to explaining the link between smoking and lung cancer, which is already known to be significant. It is estimated that 90% of lung cancers are related to smoking. The discovery of the genetic destruction smoking causes is only one part of the project to map the entire genome of the patient’s tumor and it is expected that the map will lead to many other discoveries over the next ten years. The findings will add considerable weight to the NHS’s call to prioritise anti-smoking initiatives and quell critics of the smoking ban, introduced in 2007. The NHS say that people aiming to quit smoking should seek medical help, as smoking cessation treatments such as nicotine replacement therapies and drugs like Champix and Zyban can significantly increase their chances of success.
However smoking cessation treatments, Champix and counseling for would-be smokers do not come cheaply and the NHS spends large sums each year on anti-smoking campaigns. Nonetheless, as the research provides conclusive evidence about the cancer-creating properties of tobacco, even spending hundreds to help an individual quit proves considerably cheaper than paying for the cost of cancer treatment.
Professor Carlos Caldas, of Cancer Research’s Cambridge Research Institute, called the study ‘ground breaking’. He said, “The hope and excitement for the future is that we’ll eventually have a detailed picture of how different cancers develop, and ultimately how better to treat and prevent them.”
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